Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) Antibody
286€ (100 µl)
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935106861
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name
Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx131519
tested applications
ELISA, WB, IHC, IF/ICC
Description
PTPRZ Antibody is a Rabbit Polyclonal against PTPRZ.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type Z (PTPRZ) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 0.05-2 µg/ml, WB: 1-5 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23471 |
| Alias | PTPZ,HPTPZ,PTP18,PTPRZ,RPTPB,HPTPzeta,PTP-ZETA,RPTPbeta,phosphacan,R-PTP-zeta-2,Protein-tyrosine phosphatase receptor type Z polypeptide 1,Protein-tyrosine phosphatase receptor type Z polypeptide 2,Receptor-type tyrosine-protein phosphatase zeta |
| Background | Antibody anti-PTPRZ1 |
| Status | RUO |
| Note | Concentration: 0.62 mg/ml - |
Descripción
PTPRZ1, also known as RPTPζ, is a receptor-type protein tyrosine phosphatase highly expressed in the central nervous system, particularly in glial cells and neurons. Structurally, PTPRZ1 consists of extracellular carbonic anhydrase-like and fibronectin type III domains, a single transmembrane domain, and two intracellular phosphatase domains. PTPRZ1 regulates cell proliferation, differentiation, and migration, particularly in the context of neural development and repair. It acts as a receptor for pleiotrophin and midkine, growth factors involved in neuroprotection and neural plasticity. PTPRZ1 is crucial for maintaining oligodendrocyte function and myelination in the CNS. Dysregulation or overexpression of PTPRZ1 is associated with glioblastomas, where it promotes cell migration and survival. It is also implicated in neuropsychiatric conditions such as schizophrenia due to its role in synaptic regulation and plasticity. PTPRZ1’s multifunctionality underscores its significance in neural development, repair, and tumor biology.
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