Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Antibody
351€ (100 µg)
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935106861
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name
Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx375710
tested applications
ELISA, WB
Description
Protein Tyrosine Phosphatase Receptor Type U (PTPRU) Antibody is a Rabbit Polyclonal antibody against Protein Tyrosine Phosphatase Receptor Type U (PTPRU).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type U (PTPRU) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92729 |
| Gene ID | 10076 |
| Alias | FMI,PTP,PCP-2,PTP-J,PTPRO,PTPU2,PTP-PI,PTP-RO,PTPPSI,hPTP-J,R-PTP-U,R-PTP-PSI,Protein-tyrosine phosphatase receptor omicron,Receptor-type protein-tyrosine phosphatase psi,Protein-tyrosine phosphatase J,Protein-tyrosine phosphatase pi,Pancreatic carcinoma phosphatase 2,Receptor-type tyrosine-protein phosphatase U |
| Background | Antibody anti-PTPRU |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PTPRU, also known as RPTPρ, is a receptor-like protein tyrosine phosphatase that regulates cell adhesion, migration, and differentiation. It contains extracellular immunoglobulin (Ig)-like and fibronectin type III domains, a transmembrane segment, and two intracellular phosphatase domains, with the first domain being enzymatically active. PTPRU is expressed in epithelial tissues, the nervous system, and during embryonic development. It interacts with cadherins and β-catenin, mediating cell adhesion and cytoskeletal organization. PTPRU regulates Wnt/β-catenin signaling, playing a role in cellular proliferation, differentiation, and tissue development. Its expression is developmentally regulated, and dysregulation has been linked to tumor progression in various cancers, including colorectal and breast cancer. PTPRU is also implicated in stem cell maintenance and differentiation, underscoring its importance in tissue homeostasis and development. Its ability to influence cellular adhesion and signaling makes it relevant for understanding cancer and developmental biology.
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