Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Antibody

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
Product Graph
169€ (20 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx320800
tested applications
ELISA, IHC

Description

PTPRO Antibody is a Rabbit Polyclonal against PTPRO.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Protein Tyrosine Phosphatase Receptor Type O (PTPRO)
Host
Rabbit
Reactivity
Human
Recommended Dilution
IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen Affinity Chromatography.
Size 1
20 µl
Size 2
50 µl
Size 3
100 µl
Size 4
200 µl
Size 5
1 ml
Form
Liquid
Tested Applications
ELISA, IHC
Buffer
PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q16827
Gene ID
5800
NCBI Accession
NP_002839.1, NM_002848.3, NP_109592.1, NM_030667.2
OMIM
600579
Alias
NPHS6,PTPU2,GLEPP1,PTP-OC,PTP-U2,PTPROT,R-PTP-O,Glomerular epithelial protein 1,Protein tyrosine phosphatase U2,Receptor-type tyrosine-protein phosphatase O
Background
Antibody anti-PTPRO
Status
RUO

Descripción

PTPRO, also known as GLEPP1, is a receptor-type protein tyrosine phosphatase involved in kidney function, immune regulation, and tumor suppression. Structurally, PTPRO contains extracellular Ig-like and fibronectin type III domains, a transmembrane segment, and two intracellular phosphatase domains. PTPRO is highly expressed in podocytes, specialized cells in the kidney glomerulus, where it regulates podocyte cytoskeletal organization and filtration barrier integrity. It also functions in immune cells by modulating signaling pathways related to lymphocyte activation. PTPRO has been identified as a tumor suppressor, as its loss or downregulation is associated with cancers such as lung, breast, and colorectal cancers. In the kidney, PTPRO mutations or dysfunction contribute to glomerular diseases, including nephrotic syndrome. Its role in cell growth regulation and tissue homeostasis underscores its biological importance.

Related Products

FNab06946

PTPRO antibody

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function(By similarity).

Ver Producto
P8102

Recombinant Human PTPRO

Ver Producto
abx006633

Protein Tyrosine Phosphatase Receptor Type O (PTPRO) Antibody

PTPRO Antibody is a Rabbit Polyclonal Antibody against PTPRO.

Ver Producto