Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Antibody
52€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx014804
tested applications
ELISA, WB
Description
Rabbit polyclonal antibody against PTPRN2 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92932 |
| Alias | IAR,ICAAR,PTPRP,IA-2beta,R-PTP-N2,Phogrin,Islet cell autoantigen-related protein,Receptor-type tyrosine-protein phosphatase N2 |
| Background | Antibody anti-PTPRN2 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
PTPRN2, also known as IA-2β or phogrin, is closely related to PTPRN and is predominantly expressed in neuroendocrine and neuronal tissues. Like PTPRN, PTPRN2 has a transmembrane region and an intracellular domain with a catalytically inactive phosphatase-like region. PTPRN2 plays a crucial role in insulin and neurotransmitter secretion by regulating secretory granule biogenesis, transport, and exocytosis. It is particularly involved in maintaining the structural integrity of granules and their exocytotic machinery. PTPRN2 is an autoantigen in type 1 diabetes, contributing to β-cell autoimmunity and destruction. It has also been implicated in neurological functions, including synaptic vesicle release and neurotransmitter regulation. Dysregulation of PTPRN2 has been associated with metabolic diseases and neuropsychiatric disorders, highlighting its significance in endocrine and neuronal cell function.
Related Products
Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Antibody
Rabbit polyclonal antibody against PTPRN2 protein. Immunogen region is Internal.
Ver Producto
Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Antibody
PTPRN2 Antibody is a Rabbit Polyclonal against PTPRN2.
Ver Producto
Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Antibody
PTPRN2 Antibody is a Rabbit Polyclonal against PTPRN2.
Ver Producto