Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Antibody

Name: Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2) Antibody
Brand: Abbexa
SKU: abx014804
Price: 52 EUR
Availability: OnlineOnly

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type

Pida mas información

935106861

info@markelab.com

Precio

52€ (10 µg)

Antibody anti-PTPRN2

proveedor

Abbexa

reference

abx014804

Tested Applications

ELISA, WB

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

Rabbit polyclonal antibody against PTPRN2 protein. Immunogen region is Internal.

Background

PTPRN2, also known as IA-2β or phogrin, is closely related to PTPRN and is predominantly expressed in neuroendocrine and neuronal tissues. Like PTPRN, PTPRN2 has a transmembrane region and an intracellular domain with a catalytically inactive phosphatase-like region. PTPRN2 plays a crucial role in insulin and neurotransmitter secretion by regulating secretory granule biogenesis, transport, and exocytosis. It is particularly involved in maintaining the structural integrity of granules and their exocytotic machinery. PTPRN2 is an autoantigen in type 1 diabetes, contributing to β-cell autoimmunity and destruction. It has also been implicated in neurological functions, including synaptic vesicle release and neurotransmitter regulation. Dysregulation of PTPRN2 has been associated with metabolic diseases and neuropsychiatric disorders, highlighting its significance in endocrine and neuronal cell function.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse, Rat

immunogen target

Protein Tyrosine Phosphatase Receptor Type N2 (PTPRN2)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB

purification

Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.

recommended dilution

WB: 1/500 - 1/3000, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.

size 1

10 µg

size 2

100 µg

size 3

200 µg

size 4

300 µg

size 5

1 mg

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

PTPRN2

dry ice

availability

Shipped within 5-10 working days.

alias

IAR,ICAAR,PTPRP,IA-2beta,R-PTP-N2,Phogrin,Islet cell autoantigen-related protein,Receptor-type tyrosine-protein phosphatase N2

uniprot id

https://www.uniprot.org/uniprotkb/Q92932

note

Concentration: 1 mg/ml -

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