Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Antibody (APC)

Este producto es parte de PTPR - protein tyrosine phosphatase receptor type
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429€ (100 tests)

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935106861
info@markelab.com
name
Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx139846
tested applications
FCM

Description

CD148 Antibody is a Mouse Monoclonal against CD148.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Protein Tyrosine Phosphatase Receptor Type J (PTPRJ)
Host
Mouse
Reactivity
Human
Recommended Dilution
FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
APC
Isotype
IgG2b
Clone ID
E710
Size 1
100 tests
Tested Applications
FCM
Buffer
Stabilizing PBS solution containing 15 mM sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
Q12913
Gene ID
5795
Alias
DEP1,SCC1,CD148,THC10,HPTPeta,R-PTP-J,HPTP eta,R-PTP-ETA,Protein-tyrosine phosphatase receptor type J,Density-enhanced phosphatase 1,Protein-tyrosine phosphatase eta,Receptor-type tyrosine-protein phosphatase eta
Background
Antibody anti-PTPRJ
Status
RUO

Descripción

Protein tyrosine phosphatase receptor type J (PTPRJ) is a transmembrane protein belonging to the protein tyrosine phosphatase family, which regulates cellular signaling pathways by dephosphorylating tyrosine residues on target proteins this receptor-like phosphatase is broadly expressed in various tissues including endothelial cells, immune cells, and epithelial cells and is implicated in controlling cell growth, adhesion, and migration it negatively regulates key signaling pathways such as those mediated by receptor tyrosine kinases including VEGFR, PDGFR, and EGFR, making it a critical player in angiogenesis, immune responses, and tumor suppression its reduced expression or functional inactivation has been associated with several cancers, including colorectal, thyroid, and breast cancers, where its loss promotes tumor progression and metastasis emerging studies suggest its role in modulating the immune microenvironment and its potential as a therapeutic target to enhance immune checkpoint therapies ongoing research focuses on elucidating its broader functions in cellular homeostasis and its utility in precision medicine.

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