Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Antibody
299€ (100 µl)
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Name
Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx131516
Tested Applications
IHC
Description
PTPRF Antibody is a Rabbit Polyclonal against PTPRF.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Receptor-Type Tyrosine-Protein Phosphatase F (PTPRF) Immunogen: PTPRF (Asp30-Tyr224) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10586 |
| Alias | LAR,BNAH2,Leukocyte common antigen related,Receptor-type tyrosine-protein phosphatase F |
| Background | Antibody anti-PTPRF |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTPRF, also known as leukocyte common antigen-related (LAR) protein, is a receptor-like protein tyrosine phosphatase involved in cell-cell adhesion, neuronal development, and tissue organization. Structurally, PTPRF contains extracellular immunoglobulin-like (Ig) domains, fibronectin type III domains, a single transmembrane region, and two intracellular phosphatase domains, where the first exhibits enzymatic activity. PTPRF plays a critical role in synaptic formation, axonal guidance, and neuronal differentiation through interactions with ligands like netrin-G ligands and heparan sulfate proteoglycans. It regulates focal adhesion and cytoskeletal organization by interacting with intracellular proteins such as liprin-α. Mutations or dysregulation of PTPRF have been implicated in cancers, insulin resistance, and neurological disorders, including intellectual disability and autism.
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