Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody (APC)
689€ (100 tests)
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Name
Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody (APC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270673
Tested Applications
FCM
Description
Receptor-Type Tyrosine-Protein Phosphatase C (PTPRC) Antibody (APC) is a Mouse Monoclonal Antibody conjugated to APC against Receptor-Type Tyrosine-Protein Phosphatase C (PTPRC) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) |
| Host | Mouse |
| Reactivity | Human |
| Detection Method | Laser Line: 647 Excitation/Emission: 651/660 |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | LCA,LY5,B220,CD45,L-CA,T200,CD45R,GP180,IMD105,CD45,Leukocyte common antigen,Receptor-type tyrosine-protein phosphatase C |
| Background | Antibody anti-PTPRC |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTPRC, also known as CD45, is a receptor-type tyrosine phosphatase primarily expressed in hematopoietic cells. It regulates antigen receptor signaling in lymphocytes by dephosphorylating inhibitory residues on Src family kinases such as Lck and Fyn. Structurally, PTPRC has an extracellular domain, a single transmembrane region, and two cytoplasmic phosphatase domains, with the first being catalytically active. It is critical for T-cell and B-cell activation, development, and immune response regulation. Mutations in PTPRC are linked to severe immunodeficiency disorders, including SCID, and its overexpression is associated with autoimmune diseases and leukemia.
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