proveedor
Abbexareference
abx010527Tested Applications
ELISA, IHCreactivity
Humanstatus
RUOclonality
MonoclonalDescripción
CD45, also known as TPRC (protein tyrosine phosphatase, receptor type, C). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Human
immunogen target
Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)
host
Mouse
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, IHC
purification
Unpurified ascites.
buffer
Ascitic fluid containing 0.03% sodium azide.
size 1
100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
PTPRC
dry ice
No
availability
Shipped within 5-10 working days.
uniprot id
note
This product is for research use only.
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