Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody
507€ (500 µg)
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Name
Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx137052
Description
B220 is a Rat Monoclonal against Mouse B220.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Immunogen: Purified mouse LN B cells. |
| Host | Rat |
| Reactivity | Mouse |
| Assay Type | Prior to lyophilization: 1 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgM |
| Purification | Purified by ion exchange column. |
| Size 1 | 500 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Buffer | Prior to lyophilization: PBS |
| Availability | Shipped within 5-10 working days. |
| Storage | Store lyophilized at 2°C to 8°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | LCA,LY5,B220,CD45,L-CA,T200,CD45R,GP180,IMD105,CD45,Leukocyte common antigen,Receptor-type tyrosine-protein phosphatase C |
| Background | Antibody anti-PTPRC |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTPRC, also known as CD45, is a receptor-type tyrosine phosphatase primarily expressed in hematopoietic cells. It regulates antigen receptor signaling in lymphocytes by dephosphorylating inhibitory residues on Src family kinases such as Lck and Fyn. Structurally, PTPRC has an extracellular domain, a single transmembrane region, and two cytoplasmic phosphatase domains, with the first being catalytically active. It is critical for T-cell and B-cell activation, development, and immune response regulation. Mutations in PTPRC are linked to severe immunodeficiency disorders, including SCID, and its overexpression is associated with autoimmune diseases and leukemia.
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