Protein Tyrosine Phosphatase Receptor Type B (PTPRB) Antibody
312€ (50 µl)
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935106861
info@markelab.com
name
Protein Tyrosine Phosphatase Receptor Type B (PTPRB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx218060
tested applications
WB
Description
PTPRB Antibody is a Rabbit Polyclonal against PTPRB.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Protein Tyrosine Phosphatase Receptor Type B (PTPRB) Immunogen: Synthesised peptide derived from human PTPRB |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/1000 - 1/3000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Observed MW | 224 kDa |
| Purification | Purified by affinity chromatography using epitope-specific peptide. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23467 |
| Gene ID | 5787 |
| Alias | PTPB,HPTPB,VEPTP,HPTP-BETA,R-PTP-BETA,Vascular endothelial protein tyrosine phosphatase,Protein-tyrosine phosphatase beta,Receptor-type tyrosine-protein phosphatase beta |
| Background | Antibody anti-PTPRB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
PTPRB is a member of the receptor-type protein tyrosine phosphatases (RPTPs), which regulate tyrosine phosphorylation-dependent signaling. PTPRB plays an essential role in vascular development and endothelial cell function. It has an extracellular domain, a transmembrane region, and two intracellular phosphatase domains, of which one is enzymatically active. PTPRB is expressed predominantly in endothelial cells and modulates vascular permeability, angiogenesis, and blood vessel remodeling. It is involved in suppressing VEGF receptor signaling to maintain endothelial quiescence. Dysregulation of PTPRB has been implicated in diseases such as vascular malformations and cancers involving aberrant angiogenesis.
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