Human Protein Tyrosine Phosphatase Receptor Type B (PTPRB) Protein
234€ (10 µg)
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name
Human Protein Tyrosine Phosphatase Receptor Type B (PTPRB) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx068770
tested applications
WB, SDS-PAGE
Description
Recombinant Protein Tyrosine Phosphatase Receptor Type B (PTPRB) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Protein Tyrosine Phosphatase Receptor Type B (PTPRB) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 34.1 kDa Observed MW (SDS-PAGE): 32 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala1655-Asp1918 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P23467 |
| Alias | PTPB,HPTPB,VEPTP,HPTP-BETA,R-PTP-BETA,Vascular endothelial protein tyrosine phosphatase,Protein-tyrosine phosphatase beta,Receptor-type tyrosine-protein phosphatase beta |
| Background | Protein PTPRB |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
PTPRB is a member of the receptor-type protein tyrosine phosphatases (RPTPs), which regulate tyrosine phosphorylation-dependent signaling. PTPRB plays an essential role in vascular development and endothelial cell function. It has an extracellular domain, a transmembrane region, and two intracellular phosphatase domains, of which one is enzymatically active. PTPRB is expressed predominantly in endothelial cells and modulates vascular permeability, angiogenesis, and blood vessel remodeling. It is involved in suppressing VEGF receptor signaling to maintain endothelial quiescence. Dysregulation of PTPRB has been implicated in diseases such as vascular malformations and cancers involving aberrant angiogenesis.
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