Protein Tyrosine Kinase 2 Phospho-Tyr861 (PTK2 pY861) Antibody
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Description
PTK2 (pY861) Antibody is a Rabbit Polyclonal against PTK2 (pY861).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Tyrosine Kinase 2 Phospho-Tyr861 (PTK2 pY861) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Data | Modification: Phosphorylation // Target Modification: Tyr861 |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q05397 |
| Gene ID | 5747 |
| Alias | FAK,FADK,FAK1,FRNK,FADK 1,PPP1R71,p125FAK,pp125FAK,Focal adhesion kinase-related nonkinase,Protein phosphatase 1 regulatory subunit 71,Protein-tyrosine kinase 2 |
| Background | Antibody anti-PTK2 |
| Status | RUO |
Descripción
Protein Tyrosine Kinase 2 (PTK2), also known as FAK (Focal Adhesion Kinase), is a non-receptor tyrosine kinase that plays a critical role in cell adhesion, migration, and signal transduction. PTK2 is primarily located at focal adhesion sites and is activated in response to integrin signaling and growth factor receptors. Structurally, PTK2 consists of an N-terminal FERM domain for membrane association, a central kinase domain for catalytic activity, and a C-terminal focal adhesion targeting (FAT) domain that mediates protein-protein interactions. PTK2 is crucial in cytoskeletal organization, integrin-mediated signaling, and cell motility, particularly in processes such as embryogenesis, wound healing, and angiogenesis. PTK2 is upregulated in various cancers, including breast, colorectal, and glioblastoma, where it promotes cell proliferation, survival, and metastasis. Dysregulation of PTK2 signaling can contribute to chemoresistance and increased tumor progression, making it a potential therapeutic target. In non-cancer contexts, PTK2 is essential for immune cell function, particularly for T-cell activation and macrophage responses. Additionally, PTK2 is implicated in neurological processes, such as synaptic plasticity and neuron survival. Its diverse roles make PTK2 a key mediator of cellular communication and mechanotransduction.
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