5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 (PRKAA2) Antibody
292.5€ (80 µl)
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Name
5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 (PRKAA2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx025251
Tested Applications
ELISA, WB, IF/ICC
Description
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: 5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 (PRKAA2) Immunogen: Human PRKAA2 recombinant protein. |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IF/ICC: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a Kappa |
| Observed MW | Calculated MW: 62.3 kDa |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P54646 |
| Background | Antibody anti-PRKAA2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
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