Protein Inhibitor of Activated STAT 1 (PIAS1) Antibody
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Description
PIAS1 Antibody is a Rabbit Polyclonal antibody against PIAS1. This gene encodes a member of the mammalian PIAS.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein Inhibitor of Activated STAT 1 (PIAS1) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75925 |
| Gene ID | 8554 |
| NCBI Accession | NP_057250.1 |
| Background | Antibody anti-PIAS1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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PIAS1 antibody
Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Together with PRMT1, may repress STAT1 transcriptional activity, in the late phase of interferon gamma(IFN-gamma) signaling. Sumoylates PML(at'Lys-65' and 'Lys-160') and PML-RAR and promotes their ubiquitin-mediated degradation. PIAS1-mediated sumoylation of PML promotes its interaction with CSNK2A1/CK2 which in turn promotes PML phosphorylation and degradation(By similarity). Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Plays a dynamic role in adipogenesis by promoting the SUMOylation and degradation of CEBPB(By similarity).
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Protein Inhibitor of Activated STAT 1 (PIAS1) Antibody
PIAS1 Antibody is a Rabbit Polyclonal antibody against PIAS1. This gene encodes a member of the mammalian PIAS.
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