Protein FAN (NSMAF) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Protein FAN (NSMAF) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92636 |
| Alias | FAN,GRAMD5,Protein FAN |
| Background | Antibody anti-NSMAF |
| Status | RUO |
Descripción
Neutral sphingomyelinase activation associated factor (NSMAF) is a key protein involved in the regulation of sphingomyelin metabolism, specifically in the activation of neutral sphingomyelinase (nSMase). This enzyme plays an important role in generating ceramide, a lipid molecule involved in various cellular processes, including apoptosis, cell differentiation, and membrane integrity. NSMAF functions as an activator of nSMase, and its activity is crucial for the proper regulation of sphingomyelinase signaling pathways. The activation of nSMase by NSMAF is essential for maintaining cellular homeostasis and regulating lipid metabolism, especially in response to external stimuli such as oxidative stress or inflammatory signals. Disruption of NSMAF function can lead to abnormal ceramide production, which has been linked to several diseases, including neurodegenerative conditions, cancers, and metabolic disorders. Understanding the role of NSMAF in sphingomyelinase regulation is important for developing potential therapeutic strategies targeting ceramide-related pathways in various diseases.
Related Products
Protein FAN (NSMAF) Antibody
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
Ver Producto
Neutral Sphingomyelinase Activation Associated Factor (NSMAF) Antibody
Neutral Sphingomyelinase Activation Associated Factor Antibody is a Rabbit Polyclonal against Neutral Sphingomyelinase Activation Associated Factor.
Ver Producto
Human Neutral Sphingomyelinase Activation Associated Factor (NSMAF) ELISA Kit
Human Neutral Sphingomyelinase Activation Associated Factor (NSMAF) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Neutral Sphingomyelinase Activation Associated Factor concentrations in tissue homogenates, cell lysates and other biological fluids.
Ver Producto