Prostatic Acid Phosphatase (ACPP) Antibody
312€ (60 µl)
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Name
Prostatic Acid Phosphatase (ACPP) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx001583
Tested Applications
WB
Description
ACPP Antibody is a Rabbit Polyclonal antibody against ACPP. ACPP is also named as PAP(prostatic acid phosphatase),5'-nucleotidase,thiamine monophosphatas and Belongs to the histidine acid phosphatase family.This enzyme is a homodimeric glycoprotein with a subunit molecular mass of 50 kDa and is an androgen-stimulated secretory product of the human prostate gland(PMID:8132635).It is also a non-specific phosphatase and has been implicated in the progression of prostate cancer, which inactivates LPA in human seminal plasma(PMID:15280042). This protein has three glycosylation sites(PMID:10639192;12525165). This antibody is specific to ACPP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Prostatic Acid Phosphatase (ACPP) Immunogen: Recombinant fusion protein corresponding to human ACPP |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 40 kDa/44 kDa/48 kDa Observed MW: 43 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15309 |
| Gene ID | 55 |
| NCBI Accession | NP_001090.2 |
| Alias | ACP-3,ACPP,TM-PAP |
| Background | Antibody anti-ACP3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Acid phosphatases (ACP) are a group of enzymes that catalyze the hydrolysis of phosphate ester bonds under acidic conditions, resulting in the release of inorganic phosphate from organic molecules. These enzymes are characterized by their ability to function optimally at low pH levels. There are multiple forms of acid phosphatase, often denoted as ACP1, ACP2, ACP3, ACP4, and ACP5. Each isoform may have distinct tissue distribution, substrate specificity, and physiological roles. ACP1. It is found in various tissues and body fluids, including red blood cells, bone, prostate gland, and semen. It is a biomarker for poor prognosis in prostate cancer has been linked to bad clinical prognosis. ACP3 (Prostatic Acid Phosphatase - PAP) is predominantly expressed in the prostate and hydrolyzes phosphate esters in seminal plasma and has a role in semen liquefaction.
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