Prostaglandin E Synthase, Microsomal (PTGES) Antibody
806€ (1 ml)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Prostaglandin E Synthase, Microsomal (PTGES) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx174211
tested applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Prostaglandin E Synthase, Microsomal (PTGES) |
| Host | Mouse |
| Reactivity | Rat |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | MGST1L1,MPGES1,PGES,PIG12,Microsomal prostaglandin E synthase 1,p53-induced gene 12 protein,PP1294,MGST-IV,MGST1L1,TP53I12;,mPGES-1,MGST1-L1 |
| Background | Antibody anti-PTGES |
| Status | RUO |
Descripción
Prostaglandin E synthase (PTGES) is an inducible enzyme that catalyzes the conversion of prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), a bioactive lipid mediator involved in a wide range of physiological and pathological processes, including inflammation, fever, pain perception, and tissue homeostasis. PTGES is typically upregulated in response to pro-inflammatory stimuli such as cytokines (e.g., TNF-α and IL-1β) and oxidative stress, making it a key component of the inflammatory response. It is closely associated with cyclooxygenase-2 (COX-2), as both enzymes are induced during inflammation, and they work in tandem to elevate PGE2 levels. Overexpression of PTGES has been implicated in various diseases, including cancer, rheumatoid arthritis, and cardiovascular disorders, where increased PGE2 production contributes to tumor growth, immune evasion, chronic inflammation, and vascular dysfunction. PTGES is predominantly expressed in the cytoplasm and is regulated by transcriptional and post-translational mechanisms, including phosphorylation. Targeting PTGES has emerged as a potential therapeutic strategy to modulate PGE2 levels while avoiding the side effects associated with COX inhibitors, making it an area of active pharmacological research.
Related Products
Bovine PTGES (Prostaglandin E synthase) ELISA Kit
Ver Producto
Human PTGES (Prostaglandin E synthase) ELISA Kit
Ver Producto