Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibody

Este producto es parte de PCSK9 - Proprotein Convertase Subtilisin/Kexin Type 9
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibody

Pida mas información

935106861

info@markelab.com

Precio

175€ (20 µl)

Antibody anti-PCSK9

proveedor

Abbexa

reference

abx007236

Tested Applications

WB, IF/ICC

reactivity

Human, Mouse, Rat

status

RUO

clonality

Polyclonal

Descripción

PCSK9 Antibody is a Rabbit Polyclonal Antibody against PCSK9.


Background

PCSK9 is a serine protease that plays a central role in cholesterol metabolism by regulating the levels of low-density lipoprotein receptors (LDLR) on the cell surface. PCSK9 binds to LDL receptors, promoting their internalization and subsequent degradation in lysosomes, which reduces the uptake of LDL cholesterol (LDL-C) from the bloodstream. Elevated PCSK9 activity leads to hypercholesterolemia and increases the risk of cardiovascular disease due to excessive circulating LDL-C levels. In contrast, loss-of-function mutations in PCSK9 result in reduced LDL receptor degradation, leading to low plasma cholesterol levels and decreased cardiovascular risk. PCSK9 inhibitors, such as monoclonal antibodies (e.g., alirocumab and evolocumab), are highly effective therapies for hypercholesterolemia and cardiovascular disease, as they block PCSK9's activity, preserving LDL receptors on cell surfaces to enhance cholesterol clearance. Beyond lipid metabolism, PCSK9 has been implicated in inflammation, immune regulation, and other pathological processes, making it a versatile target for therapeutic intervention. Its crucial role in cholesterol homeostasis underscores its significance in cardiovascular health and disease management.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human, Mouse, Rat


immunogen target

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)


host

Rabbit


conjugation

Unconjugated


form

Liquid


tested applications

WB, IF/ICC


purification

Purified by affinity chromatography.


buffer

PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.


size 1

20 µl


size 2

50 µl


size 3

100 µl


size 4

200 µl


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

PCSK9


dry ice

No


availability

Shipped within 5-10 working days.


alias

FH3,PC9,FHCL3,NARC1,LDLCQ1,NARC-1,HCHOLA3


NCBI accession

NP_777596.2


note

This product is for research use only.


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