Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibody
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935106861
info@markelab.com
Precio
175€ (20 µl)
Antibody anti-PCSK9
proveedor
Abbexareference
abx007236Tested Applications
WB, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
PCSK9 Antibody is a Rabbit Polyclonal Antibody against PCSK9.
Background
PCSK9 is a serine protease that plays a central role in cholesterol metabolism by regulating the levels of low-density lipoprotein receptors (LDLR) on the cell surface. PCSK9 binds to LDL receptors, promoting their internalization and subsequent degradation in lysosomes, which reduces the uptake of LDL cholesterol (LDL-C) from the bloodstream. Elevated PCSK9 activity leads to hypercholesterolemia and increases the risk of cardiovascular disease due to excessive circulating LDL-C levels. In contrast, loss-of-function mutations in PCSK9 result in reduced LDL receptor degradation, leading to low plasma cholesterol levels and decreased cardiovascular risk. PCSK9 inhibitors, such as monoclonal antibodies (e.g., alirocumab and evolocumab), are highly effective therapies for hypercholesterolemia and cardiovascular disease, as they block PCSK9's activity, preserving LDL receptors on cell surfaces to enhance cholesterol clearance. Beyond lipid metabolism, PCSK9 has been implicated in inflammation, immune regulation, and other pathological processes, making it a versatile target for therapeutic intervention. Its crucial role in cholesterol homeostasis underscores its significance in cardiovascular health and disease management.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
WB, IF/ICC
purification
Purified by affinity chromatography.
buffer
PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
size 1
20 µl
size 2
50 µl
size 3
100 µl
size 4
200 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
PCSK9
dry ice
No
availability
Shipped within 5-10 working days.
alias
FH3,PC9,FHCL3,NARC1,LDLCQ1,NARC-1,HCHOLA3
uniprot id
NCBI accession
NP_777596.2
note
This product is for research use only.
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