Prolow-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Antibody

Este producto es parte de LRP1 - LDL receptor related protein 1
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312€ (60 µl)

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935106861
info@markelab.com
name
Prolow-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001238
tested applications
IHC

Description

LRP1 Antibody is a Rabbit Polyclonal antibody against LRP1. The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010].

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Prolow-Density Lipoprotein Receptor-Related Protein 1 (LRP1)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
60 µl
Size 2
120 µl
Size 3
200 µl
Form
Liquid
Tested Applications
IHC
Buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q07954
Gene ID
4035
NCBI Accession
NP_002323.2
Alias
Prolow-density lipoprotein receptor-related protein 1,Alpha-2-macroglobulin receptor,APR,KPA,LRP,A2MR,CD91; DDH3,APOER,LRP1A,TGFBR5,IGFBP3R,IGFBP-3R,IGFBP3R1,LRP-1,Apolipoprotein E receptor
Background
Antibody anti-LRP1
Status
RUO
Note
Concentration: 1 mg/ml -

Descripción

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) is a multifunctional cell surface receptor with diverse roles in cellular processes, including endocytosis, lipid transport, signal transduction, and the regulation of inflammation. Part of the low-density lipoprotein (LDL) receptor family, LRP1 has high sequence homology with the LDL receptor but a much broader set of ligands, facilitating interactions with various proteins, such as apolipoprotein E (ApoE), tissue plasminogen activator (tPA), and matrix metalloproteinases. LRP1 is highly expressed in the liver, brain, and adipose tissues, where it plays crucial roles in metabolism, neuroprotection, and vascular health. In neurons, LRP1 mediates neuroprotective processes and is implicated in the clearance of amyloid-beta, a key protein in Alzheimer’s disease pathology. In addition to metabolic and neural roles, LRP1 impacts cellular migration and adhesion, contributing to processes related to tissue injury repair, cancer metastasis, and inflammatory diseases. Its function and widespread expression make LRP1 a focal point in therapeutic research for conditions including neurodegenerative diseases, atherosclerosis, and certain cancers.

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