Proline-Rich AKT1 Substrate 1 (AKT1S1) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Proline-Rich AKT1 Substrate 1 (AKT1S1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx148115
tested applications
ELISA, WB, IHC
Description
Proline-Rich AKT1 Substrate 1 (AKT1S1) Antibody is a Rabbit Polyclonal antibody for the detection of AKT1S1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Proline-Rich AKT1 Substrate 1 (AKT1S1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96B36 |
| Gene ID | 84335 |
| OMIM | 610221 |
| Alias | AKT1S1,PRAS40 |
| Background | Antibody anti-AKT1S1 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
AKT1S1, also known as proline-rich AKT1 substrate 1 or PRAS40, is a protein that acts as a substrate for AKT1 (Protein Kinase B, isoform 1). It plays a crucial role in regulating the mTOR (mechanistic target of rapamycin) signaling pathway, which is involved in controlling cell growth, proliferation, and survival. AKT1S1 contains proline-rich motifs that serve as docking sites for protein-protein interactions. When phosphorylated by AKT1 at specific sites, such as Serine 183, AKT1S1 dissociates from mTORC1 (mTOR Complex 1), leading to activation of mTORC1 and subsequent stimulation of protein synthesis and cell growth.The regulation of AKT1S1 by AKT1 and its involvement in mTOR signaling make it a key player in cellular processes such as cell growth, proliferation, and metabolism. Dysregulation of this pathway can contribute to various diseases, including cancer and metabolic disorders. Therefore, understanding the function of AKT1S1 and its interactions with AKT1 and mTOR is important for elucidating disease mechanisms and developing potential therapeutic strategies.
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