Prokineticin Receptor 2 (PROKR2) Antibody
442€ (200 µl)
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935106861
info@markelab.com
name
Prokineticin Receptor 2 (PROKR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431537
tested applications
P-ELISA, WB, IHC
Description
PROKR2 Antibody is a Goat Polyclonal antibody against PROKR2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Prokineticin Receptor 2 (PROKR2) Immunogen: abx616059 - Internal region: C-NGNTSFTPNFN |
| Host | Goat |
| Reactivity | Human, Rat |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 128674, 192649 |
| NCBI Accession | NP_658986.1 |
| Alias | PROKR2,GPR73b,VEGFR-2,GPR73a,GPRg2,I5E |
| Background | Antibody anti-PROKR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
PROKR2, another G protein-coupled receptor for prokineticins, shares functional overlap with PROKR1 but has distinct tissue distribution and physiological roles. It is highly expressed in the central nervous system, particularly in the hypothalamus and olfactory bulb, where it regulates circadian rhythms, neurogenesis, and reproductive function. PROKR2 couples to Gq and Gi/o proteins, stimulating phospholipase C (PLC) and MAPK pathways to regulate neuronal signaling, calcium homeostasis, and cellular responses. PROKR2 is crucial for hypothalamic-pituitary-gonadal axis function, influencing puberty onset and fertility. Mutations in PROKR2 are associated with Kallmann syndrome, characterized by delayed puberty and anosmia (loss of smell). PROKR2 also plays a role in thermoregulation, stress responses, and inflammation. Dysregulation of PROKR2 signaling contributes to reproductive disorders, sleep disturbances, and neuroinflammatory diseases. Targeting PROKR2 holds therapeutic promise for conditions such as infertility, sleep regulation disorders, and neurodevelopmental syndromes.
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