Programmed Cell Death 1 Ligand 1 (CD274) Antibody (PE)

585€ (100 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Programmed Cell Death 1 Ligand 1 (CD274) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx270913
tested applications
FCM
Description
Programmed Cell Death Protein 1 Ligand 1 (PDCD1LG1) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against Programmed Cell Death Protein 1 Ligand 1 (PDCD1LG1) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Programmed Cell Death 1 Ligand 1 (CD274) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | PE |
Isotype | IgG |
Purification | Purified by antigen-specific affinity chromatography. |
Size 1 | 100 tests |
Size 2 | 200 tests |
Size 3 | 500 tests |
Form | Liquid |
Tested Applications | FCM |
Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
Availability | Please enquire. |
Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
Dry Ice | No |
Alias | B7-H,B7H1,PDL,PD-L1,hPD-L1,PDCD1L1,PDCD1LG1,B7 homolog 1,PDCD1 ligand 1,Programmed death ligand 1,Programmed cell death 1 ligand 1 |
Background | Antibody anti-CD274 |
Status | RUO |
Descripción
CD274 molecule, also known as Programmed Death-Ligand 1 (PD-L1), is a critical component in the immune checkpoint pathway. Encoded by the CD274 gene located on chromosome 9p24.1, PD-L1 is primarily expressed on the surface of various cell types, including immune cells (such as T cells, B cells, dendritic cells, and macrophages) and non-immune cells (including epithelial and endothelial cells). Its expression can be upregulated in response to inflammatory signals, particularly interferon-gamma (IFN-γ). PD-L1 plays a vital role in maintaining immune homeostasis and preventing autoimmunity by regulating the activity of T cells. PD-L1 gained significant attention in cancer immunotherapy due to its role in tumor immune evasion. Many tumors exploit the PD-1/PD-L1 pathway to suppress anti-tumor immune responses, allowing cancer cells to escape immune surveillance
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