Programmed Cell Death 1 Ligand 1 (CD274) Antibody

637€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Programmed Cell Death 1 Ligand 1 (CD274) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx111472
tested applications
ELISA, WB, IHC, IF/ICC, FCM, IP
Description
Programmed Cell Death 1 Ligand 1 Protein Antibody is a Rabbit Polyclonal antibody against Programmed Cell Death 1 Ligand 1 Protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Programmed Cell Death 1 Ligand 1 (CD274) |
Host | Rabbit |
Reactivity | Human, Mouse, Rat |
Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Antigen Affinity Chromatography. |
Size 1 | 100 µl |
Form | Liquid |
Tested Applications | ELISA, WB, IHC, IF/ICC, FCM, IP |
Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
Availability | Shipped within 5-10 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q9NZQ7 |
Gene ID | 29126 |
NCBI Accession | NP_001254635.1, NM_001267706.1, NP_054862.1, NM_014143.3 |
OMIM | 605402 |
Alias | B7-H,B7H1,PDL,PD-L1,hPD-L1,PDCD1L1,PDCD1LG1,B7 homolog 1,PDCD1 ligand 1,Programmed death ligand 1,Programmed cell death 1 ligand 1 |
Background | Antibody anti-CD274 |
Status | RUO |
Descripción
CD274 molecule, also known as Programmed Death-Ligand 1 (PD-L1), is a critical component in the immune checkpoint pathway. Encoded by the CD274 gene located on chromosome 9p24.1, PD-L1 is primarily expressed on the surface of various cell types, including immune cells (such as T cells, B cells, dendritic cells, and macrophages) and non-immune cells (including epithelial and endothelial cells). Its expression can be upregulated in response to inflammatory signals, particularly interferon-gamma (IFN-γ). PD-L1 plays a vital role in maintaining immune homeostasis and preventing autoimmunity by regulating the activity of T cells. PD-L1 gained significant attention in cancer immunotherapy due to its role in tumor immune evasion. Many tumors exploit the PD-1/PD-L1 pathway to suppress anti-tumor immune responses, allowing cancer cells to escape immune surveillance
Related Products

APC Anti-Mouse CD274(10F.9G2)
Ver Producto
APC Anti-Human CD274(29E.2A3)
Ver Producto