Progesterone Receptor Phospho-Ser190 (PGR pS190) Antibody

Product specifications

Primary Antibodies

Progesterone Receptor Phospho-Ser190 (PGR pS190)

Rabbit

Human

Modification: Phosphorylation // Target Modification: Ser190

WB: 1/500 - 1/1000, IHC: 1/50 - 1/100, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Purified by affinity chromatography.

100 µl

Liquid

ELISA, WB, IHC, IF/ICC

PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P06401

5241

PR,NR3C3,Nuclear receptor subfamily 3 group C member 3

Antibody anti-PGR

RUO

Descripción

Progesterone receptor (PGR) is a nuclear receptor that mediates the effects of progesterone, a steroid hormone involved in regulating the female reproductive system and various physiological processes PGR plays a key role in processes such as the menstrual cycle, pregnancy, and embryogenesis It functions by binding to progesterone, which activates the receptor and induces changes in gene expression that control cell differentiation, apoptosis, and immune responses During pregnancy, PGR helps maintain uterine function and supports the development of the fetus In the menstrual cycle, it helps regulate the endometrial lining, preparing it for implantation of a fertilized egg In addition, PGR is involved in the regulation of breast tissue, where its activation is essential for mammary gland development and function Dysregulation of PGR signaling has been associated with various diseases, including hormone-driven cancers like breast cancer and endometrial cancer, where altered progesterone signaling contributes to tumor growth and progression PGR is also a target for therapies such as progestins used in birth control and hormone replacement therapies

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This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.

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