Procollagen Type I N-Terminal Propeptide (PINP) Antibody
325€ (100 µl)
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935106861
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name
Procollagen Type I N-Terminal Propeptide (PINP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx103755
tested applications
WB, IHC, IF/ICC
Description
Polyclonal Antibody to Procollagen I N-Terminal Propeptide (PINP).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Procollagen Type I N-Terminal Propeptide (PINP) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.4, containing 0.02% NaN3, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P02452 |
| Alias | PINP,P1NP |
| Background | Antibody anti-PINP |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Procollagen Type I N-Terminal Propeptide (PINP) is a cleavage product released during the biosynthesis of type I collagen, which is the most abundant collagen type found in bones, skin, and connective tissues. It serves as a sensitive and specific biomarker for bone formation, reflecting the activity of osteoblasts and the overall rate of collagen synthesis. PINP is widely used in clinical and research settings to monitor bone metabolism, particularly in conditions such as osteoporosis, Paget's disease, and metabolic bone disorders. It is often measured to assess the effectiveness of anabolic or anti-resorptive treatments in improving bone health. PINP levels can also indicate increased collagen turnover in fibrotic diseases, including liver fibrosis and systemic sclerosis, where excessive extracellular matrix production occurs. PINP exists in two forms in circulation, the intact trimer and a smaller monomer, both of which are measurable through immunoassays. The protein's dynamic association with bone remodeling and extracellular matrix synthesis underscores its importance as a marker for tissue repair and fibrotic activity. Emerging research highlights its potential in oncology, where altered PINP levels are linked to metastatic bone disease and tumor-induced bone resorption.
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