Procollagen Type I C-Terminal Propeptide (PICP) Antibody
273€ (100 µl)
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935106861
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name
Procollagen Type I C-Terminal Propeptide (PICP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx178089
tested applications
WB, IHC, IF/ICC
Description
Procollagen I C-Terminal Propeptide (PICP) Antibody is a Rabbit Polyclonal antibody against Procollagen I C-Terminal Propeptide (PICP).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Procollagen Type I C-Terminal Propeptide (PICP) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | C-Propeptide Of Type I Procollagen,Procollagen I Carboxy Terminal Propeptide, P1CP |
| Background | Antibody anti-PICP |
| Status | RUO |
Descripción
Procollagen Type I C-Terminal Propeptide (PICP) is a cleavage product of type I procollagen, the precursor of type I collagen, which is the most abundant structural protein in the extracellular matrix of connective tissues. PICP is released into the bloodstream during the synthesis of type I collagen, making it a reliable biomarker for collagen synthesis and turnover. It is widely used in clinical and research settings to assess bone formation, as increased levels of PICP correlate with osteoblast activity and are indicative of bone remodeling or conditions such as osteoporosis and metabolic bone diseases. Elevated PICP levels can also occur in fibrotic conditions, including liver fibrosis, cardiac fibrosis, and certain cancers, reflecting excessive collagen deposition in affected tissues. Measurement of PICP is typically performed using immunoassays, and its levels can provide insight into the effectiveness of therapeutic interventions aimed at modulating collagen synthesis or tissue remodeling. Additionally, PICP is a key player in the assembly and stabilization of collagen fibrils, facilitating proper extracellular matrix organization. Dysregulation of PICP processing or collagen deposition can lead to pathological states, highlighting its importance in connective tissue health and disease.
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