Human PICP (C-terminal propeptide of Collagen alpha-1 (I) chain) ELISA Kit
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Name
Human PICP (C-terminal propeptide of Collagen alpha-1 (I) chain) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH0957
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 62.5-4000pg/ml |
| Sensitivity | 37.5pg/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| Alias | C-Propeptide Of Type I Procollagen,Procollagen I Carboxy Terminal Propeptide, P1CP |
| Background | Elisa kits for PICP |
| Status | RUO |
Background
Procollagen Type I C-Terminal Propeptide (PICP) is a cleavage product of type I procollagen, the precursor of type I collagen, which is the most abundant structural protein in the extracellular matrix of connective tissues. PICP is released into the bloodstream during the synthesis of type I collagen, making it a reliable biomarker for collagen synthesis and turnover. It is widely used in clinical and research settings to assess bone formation, as increased levels of PICP correlate with osteoblast activity and are indicative of bone remodeling or conditions such as osteoporosis and metabolic bone diseases. Elevated PICP levels can also occur in fibrotic conditions, including liver fibrosis, cardiac fibrosis, and certain cancers, reflecting excessive collagen deposition in affected tissues. Measurement of PICP is typically performed using immunoassays, and its levels can provide insight into the effectiveness of therapeutic interventions aimed at modulating collagen synthesis or tissue remodeling. Additionally, PICP is a key player in the assembly and stabilization of collagen fibrils, facilitating proper extracellular matrix organization. Dysregulation of PICP processing or collagen deposition can lead to pathological states, highlighting its importance in connective tissue health and disease.
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