Pro-neuregulin-4, membrane-bound isoform (NRG4) Antibody
169€ (20 µl)
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Name
Pro-neuregulin-4, membrane-bound isoform (NRG4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx348442
Tested Applications
ELISA, IF/ICC
Description
Pro-neuregulin-4, membrane-bound isoform (NRG4) Antibody is a Rabbit Polyclonal antibody for the detection of Human NRG4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Pro-neuregulin-4, membrane-bound isoform (NRG4) Immunogen: Recombinant Human Pro-neuregulin-4, membrane-bound isoform protein (1-115 AA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WWG1 |
| Alias | HRG4,Pro-NRG4,Pro-neuregulin-4 membrane-bound isoform |
| Background | Antibody anti-NRG4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Neuregulin 4 (NRG4) is a member of the neuregulin family, which consists of growth factors that play critical roles in cell signaling, development, and homeostasis. NRG4 primarily acts through the ErbB family of receptor tyrosine kinases, notably interacting with ErbB4 to initiate downstream signaling pathways. This signaling is involved in a variety of physiological processes, including metabolism, tissue repair, and the regulation of energy balance. Research suggests that NRG4 may have protective roles in metabolic disorders, such as obesity and type 2 diabetes, by modulating insulin sensitivity and inflammatory responses in key tissues like the liver and adipose tissue. Additionally, NRG4's role in neuronal and cardiac development has also been noted, highlighting its importance across diverse biological systems. Further exploration of NRG4's signaling mechanisms may provide valuable insights into therapeutic strategies for metabolic and neurodegenerative diseases.
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