Neuregulin 4 (NRG4) Antibody
312€ (60 µl)
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935106861
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name
Neuregulin 4 (NRG4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx002032
tested applications
IHC
Description
NRG4 Antibody is a Rabbit Polyclonal antibody against NRG4. The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Neuregulin 4 (NRG4) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WWG1 |
| Gene ID | 145957 |
| NCBI Accession | NP_612640.1 |
| Alias | HRG4,Pro-NRG4,Pro-neuregulin-4 membrane-bound isoform |
| Background | Antibody anti-NRG4 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Neuregulin 4 (NRG4) is a member of the neuregulin family, which consists of growth factors that play critical roles in cell signaling, development, and homeostasis. NRG4 primarily acts through the ErbB family of receptor tyrosine kinases, notably interacting with ErbB4 to initiate downstream signaling pathways. This signaling is involved in a variety of physiological processes, including metabolism, tissue repair, and the regulation of energy balance. Research suggests that NRG4 may have protective roles in metabolic disorders, such as obesity and type 2 diabetes, by modulating insulin sensitivity and inflammatory responses in key tissues like the liver and adipose tissue. Additionally, NRG4's role in neuronal and cardiac development has also been noted, highlighting its importance across diverse biological systems. Further exploration of NRG4's signaling mechanisms may provide valuable insights into therapeutic strategies for metabolic and neurodegenerative diseases.
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