pregnancy Associated Plasma Protein A (PAPP-A) Antibody
949€ (1 mg)
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Name
pregnancy Associated Plasma Protein A (PAPP-A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx021235
Tested Applications
ELISA, IP
Description
PAPP-A Antibody is a Mouse monoclonal antibody for hormones and steroids against PAPP-A. The antibody was obtained from cell cultures of hybridized Sp2/0 myeloma cells with spleen cells from BALB/c mice.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: pregnancy Associated Plasma Protein A (PAPP-A) Immunogen: Purified human PAPP-A/proMBP heterotetrameric complex (htPAPP-A). |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purification | Purified from ascites by Protein A chromatography. |
| Size 1 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IP |
| Buffer | PBS, pH 7.4, 0.09% NaN3. |
| Availability | Shipped within 10-20 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. |
| Dry Ice | No |
| Alias | PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase |
| Background | Antibody anti-PAPPA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PAPPA, also known as pregnancy-associated plasma protein-A, is a zinc-binding metalloproteinase that regulates the activity of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins (IGFBPs), specifically IGFBP-4 and IGFBP-5. This proteolytic activity increases the bioavailability of IGFs, which are crucial for cell growth, proliferation, and tissue repair. PAPPA is highly expressed during pregnancy, where it contributes to placental development and fetal growth, making it a key biomarker in prenatal screening for conditions like preeclampsia and Down syndrome. Outside of pregnancy, PAPPA is involved in regulating processes such as bone remodeling, wound healing, and inflammation. Elevated PAPPA expression has been observed in cardiovascular diseases and certain cancers, where it promotes IGF-mediated cell proliferation and tumor progression. Its role in modulating IGF signaling highlights its importance in both physiological and pathological conditions.
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