PPARGC1A Antibody
455€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
PPARGC1A Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx159654
tested applications
ELISA, WB
Description
PPARGC1A Antibody is a Mouse Monoclonal against PPARGC1A.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | PPARGC1A |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/5000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UBK2 |
| Alias | LEM6,PGC1,PGC1A,PGC-1v,PPARGC1,PGC-1alpha,PGC-1(alpha) |
| Background | Antibody anti-PPARGC1A |
| Status | RUO |
Descripción
PPARGC1A, also known as PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha), is a transcriptional coactivator that plays a central role in the regulation of cellular energy metabolism and mitochondrial biogenesis. PPARGC1A interacts with and coactivates various transcription factors, including peroxisome proliferator-activated receptor gamma (PPARG) and nuclear respiratory factors (NRFs), to regulate the expression of genes involved in energy metabolism, oxidative phosphorylation, and mitochondrial function. It promotes the transcription of genes involved in fatty acid oxidation, glucose metabolism, and thermogenesis, thereby enhancing cellular energy production and expenditure. PPARGC1A is a master regulator of mitochondrial biogenesis, the process by which new mitochondria are formed. It stimulates the expression of nuclear-encoded mitochondrial genes and activates signaling pathways involved in mitochondrial biogenesis, such as the PPAR signaling pathway and the AMP-activated protein kinase (AMPK) pathway. Increased PPARGC1A activity leads to the proliferation and remodeling of mitochondria, resulting in enhanced cellular energy capacity and metabolic efficiency.
Related Products
Human PPARGC1A (Peroxisome prolifeRator-activated receptor gamma coactivator 1-alpha) ELISA Kit
Ver Producto
Human PPARGC1A (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) ELISA Kit
Ver Producto
PPARGC1A antibody
PPARGC1A, also named as Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, is a 798 amino acid protein, which Contains 1 RRM(RNA recognition motif) domain and localizes in the nucleus. PPARGC1A is transcriptional coactivator for steroid receptors and nuclear receptors. PPARGC1A can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis and plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism.
Ver Producto