PPARGC1A Peptide
364€ (5 mg)
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Name
PPARGC1A Peptide
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx265645
Description
Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (205–216) is a peptide.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Peroxisome Proliferator Activated Receptor Gamma Coactivator 1 Alpha (205-216) |
| Assay Type | Sequence Fragment: 205-216 AA |
| Conjugation | Unconjugated |
| Observed MW | 1464.75 Da |
| Purity | > 95% (HPLC) |
| Size 1 | 5 mg |
| Size 2 | 10 mg |
| Size 3 | 25 mg |
| Form | Lyophilized |
| Buffer | Not applicable. |
| Availability | Shipped within 10-20 working days. |
| Storage | Store dry at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | LEM6,PGC1,PGC1A,PGC-1v,PPARGC1,PGC-1alpha,PGC-1(alpha) |
| Background | Protein PPARGC1A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PPARGC1A, also known as PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha), is a transcriptional coactivator that plays a central role in the regulation of cellular energy metabolism and mitochondrial biogenesis. PPARGC1A interacts with and coactivates various transcription factors, including peroxisome proliferator-activated receptor gamma (PPARG) and nuclear respiratory factors (NRFs), to regulate the expression of genes involved in energy metabolism, oxidative phosphorylation, and mitochondrial function. It promotes the transcription of genes involved in fatty acid oxidation, glucose metabolism, and thermogenesis, thereby enhancing cellular energy production and expenditure. PPARGC1A is a master regulator of mitochondrial biogenesis, the process by which new mitochondria are formed. It stimulates the expression of nuclear-encoded mitochondrial genes and activates signaling pathways involved in mitochondrial biogenesis, such as the PPAR signaling pathway and the AMP-activated protein kinase (AMPK) pathway. Increased PPARGC1A activity leads to the proliferation and remodeling of mitochondria, resulting in enhanced cellular energy capacity and metabolic efficiency.
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