Potassium Voltage-Gated Channel Subfamily A Member 4 (KCNA4) Antibody

Human KCNA4 (Potassium voltage-gated channel subfamily A member 4) ELISA Kit

KCNA4-Specific antibody

KCNA4, also named as KCNA4L, HBK4, HUKII, HK1 and HPCN2, belongs to the potassium channel family and A(Shaker) subfamily. KCN4 mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The antibody is specific to KCN4.

Potassium Voltage-Gated Channel Subfamily A Member 4 (KCNA4) Antibody

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes shaker, shaw, shab, and shal have been identified in Drosophila, and each has been shown to have human homolog (s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.