Potassium Intermediate Small Conductance Calcium Activated Channel Subfamily N, Member 1 (KCNN1) Antibody
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Description
Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 1 Antibody is a Rabbit Polyclonal antibody against Potassium Intermediate/Small Conductance Calcium-Activated Channel, Subfamily N, Member 1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Potassium Intermediate Small Conductance Calcium Activated Channel Subfamily N, Member 1 (KCNN1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92952 |
| Gene ID | 3780 |
| NCBI Accession | NP_002239.2, NM_002248.4 |
| OMIM | 602982 |
| Background | Antibody anti-KCNN1 |
| Status | RUO |
Descripción
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Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin(By similarity).
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Potassium Intermediate Small Conductance Calcium Activated Channel Subfamily N, Member 1 (KCNN1) Antibody
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes.
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