Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Antibody (Biotin)

Este producto es parte de ALOX - Arachidonate lipoxygenase
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377€ (200 µl)

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935106861
info@markelab.com
name
Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx272069
tested applications
WB, IHC, IF/ICC

Description

Arachidonate-15-Lipoxygenase (ALOX15) Antibody (Biotin) is a Rabbit Polyclonal antibody (

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Polyunsaturated Fatty Acid Lipoxygenase ALOX15 (ALOX15)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purification
Purified by antigen-specific affinity chromatography.
Size 1
200 µl
Size 2
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
ALOX15,LOG15
Background
Antibody anti-ALOX15
Status
RUO
Note
Concentration: 0.4 mg/ml - 

Descripción

ALOX15 catalyzes the oxygenation of arachidonic acid and linoleic acid to generate 15(S)-hydroperoxyeicosatetraenoic acid [15(S)-HPETE] and 13(S)-hydroxyoctadecadienoic acid (13(S)-HODE), respectively. These lipid intermediates are precursors for resolvins, protectins, and other specialized pro-resolving mediators (SPMs) involved in the resolution of inflammation. ALOX15 is highly expressed in reticulocytes, macrophages, and epithelial cells, where it plays roles in redox regulation, membrane remodeling, and anti-inflammatory responses. In macrophages, ALOX15 promotes the clearance of apoptotic cells (efferocytosis) and contributes to tissue homeostasis during inflammation resolution. Dysregulation of ALOX15 is associated with various pathological conditions, including asthma, atherosclerosis, diabetes, and neurodegenerative diseases. In cancer biology, ALOX15 has dual roles, acting as both a tumor suppressor by inhibiting proliferation and a pro-tumorigenic factor in specific contexts. Its ability to generate lipid mediators essential for resolving inflammation highlights its therapeutic potential in chronic inflammatory and metabolic disorders.

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