Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) Antibody

Este producto es parte de ALOX - Arachidonate lipoxygenase
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273€ (100 µl)

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935106861
info@markelab.com
name
Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx128821
tested applications
WB, IHC, IF/ICC

Description

Arachidonate-12-Lipoxygenase Antibody is a Rabbit Polyclonal against Arachidonate-12-Lipoxygenase.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Purification
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
Size 1
100 µl
Size 2
200 µl
Size 3
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-7 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P18054
Alias
ALOX12,12LO,LOG12
Background
Antibody anti-ALOX12
Status
RUO

Descripción

ALOX12 is a member of the lipoxygenase enzyme family that catalyzes the oxygenation of arachidonic acid to produce 12(S)-hydroperoxyeicosatetraenoic acid [12(S)-HPETE], which is further reduced to 12(S)-HETE. This reaction is critical for the biosynthesis of lipid mediators involved in inflammation, platelet aggregation, and cellular signaling. ALOX12 is highly expressed in platelets and plays a significant role in hemostasis and thrombosis by modulating platelet activation and aggregation. In addition to its role in normal physiological processes, dysregulation of ALOX12 is associated with inflammation, atherosclerosis, and cancer progression. ALOX12-derived lipid mediators contribute to tumor microenvironment remodeling, promoting cell proliferation, migration, and angiogenesis. In neurodegenerative diseases, ALOX12 activity has been implicated in oxidative stress and neuronal injury, particularly in conditions like Parkinson's disease. Its role in inflammatory and oxidative processes makes ALOX12 a promising therapeutic target for cardiovascular, cancer, and neuroinflammatory diseases.

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