Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) Antibody
273€ (100 µl)
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Name
Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx128821
Tested Applications
IHC
Description
Arachidonate-12-Lipoxygenase Antibody is a Rabbit Polyclonal against Arachidonate-12-Lipoxygenase.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Polyunsaturated Fatty Acid Lipoxygenase ALOX12 (ALOX12) Immunogen: ALOX12 (Phe352-Cys656) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P18054 |
| Alias | ALOX12,12LO,LOG12 |
| Background | Antibody anti-ALOX12 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALOX12 is a member of the lipoxygenase enzyme family that catalyzes the oxygenation of arachidonic acid to produce 12(S)-hydroperoxyeicosatetraenoic acid [12(S)-HPETE], which is further reduced to 12(S)-HETE. This reaction is critical for the biosynthesis of lipid mediators involved in inflammation, platelet aggregation, and cellular signaling. ALOX12 is highly expressed in platelets and plays a significant role in hemostasis and thrombosis by modulating platelet activation and aggregation. In addition to its role in normal physiological processes, dysregulation of ALOX12 is associated with inflammation, atherosclerosis, and cancer progression. ALOX12-derived lipid mediators contribute to tumor microenvironment remodeling, promoting cell proliferation, migration, and angiogenesis. In neurodegenerative diseases, ALOX12 activity has been implicated in oxidative stress and neuronal injury, particularly in conditions like Parkinson's disease. Its role in inflammatory and oxidative processes makes ALOX12 a promising therapeutic target for cardiovascular, cancer, and neuroinflammatory diseases.
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