Polyubiquitin-B (UBB) Antibody
383.5€ (100 µl)
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Name
Polyubiquitin-B (UBB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx016018
Tested Applications
ELISA, WB, FCM
Description
This gene encodes ubiquitin, one of the most conserved proteins known.Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover.Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation.Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression.This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence.Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat.Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Polyubiquitin-B (UBB) Immunogen: Purified recombinant fragment of human UBB expressed in E. coli. |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | 26 kDa |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P0CG47 |
| Gene ID | 7314 |
| NCBI Accession | BAC56955.1 |
| OMIM | 191339 |
| Background | Antibody anti-UBB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
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