Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Antibody
169€ (20 µl)
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Name
Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx321073
Tested Applications
ELISA, IHC
Description
PDGFRL Antibody is a Rabbit Polyclonal against PDGFRL.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Platelet Derived Growth Factor Receptor Like Protein (PDGFRL) Immunogen: Recombinant human Platelet-derived growth factor receptor-like protein (15-205AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15198 |
| Gene ID | 5157 |
| OMIM | 114500 |
| Alias | PDGRL,PRLTS,PDGF receptor beta-like tumor suppressor,PDGFR-like protein |
| Background | Antibody anti-PDGFRL |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Platelet derived growth factor receptor like (PDGFRL) lacks intrinsic kinase activity and is thought to function in the regulation of extracellular matrix components and intercellular communication although its precise role is less defined compared to PDGFRA and PDGFRB mutations in PDGFRL have been linked to tumor suppressor activity in colorectal and gastric cancers suggesting it may act as a modulator of growth factor signaling networks its reduced expression has been correlated with increased tumor invasiveness and metastasis in some cancers indicating its potential importance in maintaining cellular homeostasis ongoing research seeks to clarify its role in cellular signaling and its impact on cancer progression and therapeutic resistance.
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