Platelet Derived Growth Factor Receptor Alpha (PDGFRA) Antibody
364€ (100 µg)
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935106861
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name
Platelet Derived Growth Factor Receptor Alpha (PDGFRA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx240240
tested applications
ELISA, WB
Description
Platelet Derived Growth Factor Receptor Alpha (PDGFRA) Antibody is a Mouse Monoclonal antibody for the detection of PDGFRA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Platelet Derived Growth Factor Receptor Alpha (PDGFRA) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000 - 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.4, containing 0.1% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P16234 |
| Gene ID | 5175 |
| OMIM | 173490 |
| Alias | CD140A,PDGFR2,PDGFR-2,Platelet-derived growth factor receptor 2,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A |
| Background | Antibody anti-PDGFRA |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Platelet derived growth factor receptor alpha (PDGFRA) is a tyrosine kinase receptor that binds specifically to platelet-derived growth factors (PDGFs), initiating intracellular signaling cascades that regulate cell proliferation, differentiation, and migration in a variety of tissues during development and wound healing it is predominantly expressed in mesenchymal cells and plays a key role in the development of the cardiovascular system, smooth muscle cells, and connective tissue its activation promotes pathways like the MAPK and PI3K-AKT signaling axes, which are critical for cellular responses such as survival and proliferation mutations or overexpression of PDGFRA are frequently associated with oncogenesis in gastrointestinal stromal tumors (GISTs) and other cancers making it a target for tyrosine kinase inhibitors like imatinib further studies are exploring its role in tissue repair and fibrosis, revealing its potential in therapeutic interventions for chronic inflammatory and fibrotic diseases.
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