Platelet Derived Growth Factor Receptor Alpha (PDGFRA) Antibody
195€ (20 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Platelet Derived Growth Factor Receptor Alpha (PDGFRA) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx001715
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
PDGFRA Antibody is a Rabbit Polyclonal antibody against PDGFRA. This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Platelet Derived Growth Factor Receptor Alpha (PDGFRA) Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 896-1059 of human PDGFR alpha. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 123 kDa Observed MW: 150-190 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P16234 |
| Gene ID | 5156 |
| NCBI Accession | NP_006197.1 |
| Alias | CD140A,PDGFR2,PDGFR-2,Platelet-derived growth factor receptor 2,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A |
| Background | Antibody anti-PDGFRA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Platelet derived growth factor receptor alpha (PDGFRA) is a tyrosine kinase receptor that binds specifically to platelet-derived growth factors (PDGFs), initiating intracellular signaling cascades that regulate cell proliferation, differentiation, and migration in a variety of tissues during development and wound healing it is predominantly expressed in mesenchymal cells and plays a key role in the development of the cardiovascular system, smooth muscle cells, and connective tissue its activation promotes pathways like the MAPK and PI3K-AKT signaling axes, which are critical for cellular responses such as survival and proliferation mutations or overexpression of PDGFRA are frequently associated with oncogenesis in gastrointestinal stromal tumors (GISTs) and other cancers making it a target for tyrosine kinase inhibitors like imatinib further studies are exploring its role in tissue repair and fibrosis, revealing its potential in therapeutic interventions for chronic inflammatory and fibrotic diseases.
Productos relacionados
Platelet Derived Growth Factor Receptor Alpha (PDGFRA) Antibody
PDGFRA Antibody is a Rabbit Polyclonal antibody against PDGFRA. This gene encodes a cell surface tyrosine kinase recepto…
Ver producto
Platelet Derived Growth Factor Receptor Alpha (PDGFRA) Antibody
Rabbit polyclonal antibody against PDGFR alpha protein. Immunogen region is C-terminal.…
Ver producto
Mouse Pdgfra Antibody
Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.…
Ver producto