Platelet-activating factor receptor (PTAFR) Antibody
221€ (50 µg)
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Name
Platelet-activating factor receptor (PTAFR) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx326360
Tested Applications
ELISA, IF/ICC
Description
PTAFR Antibody is a Rabbit Polyclonal against PTAFR.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Platelet-activating factor receptor (PTAFR) Immunogen: Synthesized peptide derived from the Internal region of human PAF-R. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P25105 |
| Gene ID | 5724 |
| Alias | PTAFR,PAFr,AGEPC receptor |
| Background | Antibody anti-PTAFR |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
PTAFR is a G protein-coupled receptor activated by platelet-activating factor (PAF), a potent phospholipid mediator involved in inflammation, immune responses, and thrombosis. PTAFR is widely expressed on platelets, endothelial cells, leukocytes, and in various tissues, where it mediates diverse inflammatory and immune responses. Upon activation, PTAFR couples to Gq and Gi proteins, leading to calcium mobilization, activation of phospholipase C (PLC), and downstream signaling pathways that promote chemotaxis, cytokine release, and oxidative stress. PTAFR plays a central role in allergic reactions, asthma, cardiovascular dysfunction, and sepsis by amplifying inflammatory cascades and vascular permeability. Dysregulation of PTAFR is associated with chronic inflammatory diseases, ischemic injuries, and immune-related conditions. PTAFR antagonists are being explored as potential therapeutics for asthma, sepsis, and cardiovascular diseases by suppressing excessive PAF-mediated inflammation and thrombosis. Its involvement in inflammation and vascular responses positions PTAFR as a critical target for treating immune and inflammatory disorders.
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