Plasma Protease C1 Inhibitor (SERPING1) Antibody
221€ (50 µg)
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Name
Plasma Protease C1 Inhibitor (SERPING1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx324635
Tested Applications
ELISA, WB, IHC
Description
SERPING1 Antibody is a Rabbit Polyclonal against SERPING1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Plasma Protease C1 Inhibitor (SERPING1) Immunogen: Synthesized peptide derived from the Internal region of human C1INH. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/40000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05155 |
| Gene ID | 710 |
| Alias | C1IN,C1NH,HAE1,HAE2,C1INH,Plasma protease C1 inhibitor,C1 esterase inhibitor,C1-inhibiting factor |
| Background | Antibody anti-SERPING1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
SERPING1, also known as C1 esterase inhibitor (C1-INH), is a serine protease inhibitor that plays a critical role in regulating the complement system, a part of the immune response. SERPING1 is primarily responsible for controlling the activation of the C1 complex in the classical pathway of complement activation. Beyond complement regulation, it also inhibits several other proteases involved in the coagulation, fibrinolytic, and kinin-generating systems. SERPING1 mutations or deficiencies are strongly linked to hereditary angioedema (HAE), a potentially life-threatening condition characterized by uncontrolled swelling. SERPING1 is an important therapeutic target in diseases where inappropriate immune activation or excessive protease activity leads to tissue damage or inflammation. It is mainly synthesized in the liver and secreted into the bloodstream, where it circulates and exerts its regulatory effects.
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