Plasma Protease C1 Inhibitor (SERPING1) Antibody (FITC)
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Description
SERPING1 Antibody (FITC) is a Rabbit Polyclonal against SERPING1 conjugated to FITC.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Plasma Protease C1 Inhibitor (SERPING1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05155 |
| Gene ID | 710 |
| NCBI Accession | NP_000053.2, NM_000062.2 |
| OMIM | 106100 |
| Alias | C1IN,C1NH,HAE1,HAE2,C1INH,Plasma protease C1 inhibitor,C1 esterase inhibitor,C1-inhibiting factor |
| Background | Antibody anti-SERPING1 |
| Status | RUO |
| Note | Concentration: 0.25 mg/ml - |
Descripción
SERPING1, also known as C1 esterase inhibitor (C1-INH), is a serine protease inhibitor that plays a critical role in regulating the complement system, a part of the immune response. SERPING1 is primarily responsible for controlling the activation of the C1 complex in the classical pathway of complement activation. Beyond complement regulation, it also inhibits several other proteases involved in the coagulation, fibrinolytic, and kinin-generating systems. SERPING1 mutations or deficiencies are strongly linked to hereditary angioedema (HAE), a potentially life-threatening condition characterized by uncontrolled swelling. SERPING1 is an important therapeutic target in diseases where inappropriate immune activation or excessive protease activity leads to tissue damage or inflammation. It is mainly synthesized in the liver and secreted into the bloodstream, where it circulates and exerts its regulatory effects.
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