Pig Thyrotropin receptor (TSHR) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Pig Thyrotropin receptor (TSHR) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx521358
tested applications
ELISA
Description
Pig Thyrotropin receptor (TSHR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Pig Thyrotropin receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Thyrotropin receptor (TSHR) |
| Reactivity | Pig |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8SPP9 |
| Alias | TSHR,Thyrotropin Receptor,LGR3,TSH-R,CHNG1,hTSHR-I |
| Background | Elisa kits for TSHR |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
TSHR is a G protein-coupled receptor activated by thyroid-stimulating hormone (TSH), a pituitary hormone that regulates thyroid gland growth and function. TSHR is primarily expressed on thyroid follicular cells, where its activation stimulates the production and release of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). TSHR signaling occurs via Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and stimulation of thyroid hormone synthesis, iodide uptake, and cell proliferation. TSHR plays a critical role in maintaining metabolic homeostasis, thermoregulation, and growth. Dysregulation of TSHR signaling is associated with thyroid disorders, such as Graves' disease (autoimmune hyperthyroidism), where TSHR autoantibodies lead to excessive hormone production, and hypothyroidism caused by receptor mutations. TSHR is also a target in thyroid cancers, where its overactivation promotes tumor growth. TSHR agonists and antagonists are being explored for therapeutic applications in thyroid dysfunction and thyroid-related cancers. TSHR is central to thyroid hormone regulation and overall metabolic balance.
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The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
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