anti- TSHR antibody
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935106861
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name
anti- TSHR antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09045
tested applications
ELISA, WB, IHC, IF
Description
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | thyroid stimulating hormone receptor |
| Host | Rabbit |
| Reactivity | human,mouse,rat |
| Recommended Dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:20- 1:50 |
| Clonality | polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | 110 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Immunogen affinity purified |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC, IF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P16473 |
| Gene ID | 7253 |
| Alias | TSHR,Thyrotropin Receptor,LGR3,TSH-R,CHNG1,hTSHR-I |
| Background | Antibody anti-TSHR |
| Status | RUO |
| Note | This product is for research use only. |
Descripción
TSHR is a G protein-coupled receptor activated by thyroid-stimulating hormone (TSH), a pituitary hormone that regulates thyroid gland growth and function. TSHR is primarily expressed on thyroid follicular cells, where its activation stimulates the production and release of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). TSHR signaling occurs via Gs proteins, leading to activation of adenylyl cyclase, increased cAMP levels, and stimulation of thyroid hormone synthesis, iodide uptake, and cell proliferation. TSHR plays a critical role in maintaining metabolic homeostasis, thermoregulation, and growth. Dysregulation of TSHR signaling is associated with thyroid disorders, such as Graves' disease (autoimmune hyperthyroidism), where TSHR autoantibodies lead to excessive hormone production, and hypothyroidism caused by receptor mutations. TSHR is also a target in thyroid cancers, where its overactivation promotes tumor growth. TSHR agonists and antagonists are being explored for therapeutic applications in thyroid dysfunction and thyroid-related cancers. TSHR is central to thyroid hormone regulation and overall metabolic balance.
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anti- TSHR antibody
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
Ver Producto