Pig Lipopolysaccharide Binding Protein (LBP) Protein

Este producto es parte de LBP - Lipopolysaccharide binding protein
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455€ (50 µg)

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935106861
info@markelab.com
name
Pig Lipopolysaccharide Binding Protein (LBP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166137
tested applications
WB, SDS-PAGE

Description

Pig Lipopolysaccharide Binding Protein (LBP) is a recombinant Pig protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Lipopolysaccharide Binding Protein (LBP)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Asn36-Thr474
Tag: N-terminal His tag
Origin
Pig
Conjugation
Unconjugated
Observed MW
Calculated MW: 56.5 kDa  Observed MW (SDS-PAGE): 57 kDa
Expression
Recombinant
Purity
> 97%
Size 1
50 µg
Size 2
100 µg
Size 3
200 µg
Size 4
500 µg
Size 5
1 mg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
BPIFD2,BPI Fold Containing Family D,LPS-Binding Protein 3
Background
Protein LBP
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

LBP is an acute-phase protein produced mainly by the liver in response to infections and inflammation It plays a crucial role in innate immunity by binding to lipopolysaccharides (LPS) from the outer membrane of Gram-negative bacteria and delivering them to CD14 and Toll-like receptor 4 (TLR4) complexes on immune cells This process triggers signaling pathways that lead to the production of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, initiating immune defense against bacterial infections Elevated LBP levels are observed in sepsis, systemic inflammatory response syndrome (SIRS), and chronic inflammatory diseases Dysregulation of LBP contributes to endotoxemia, where excessive immune activation results in tissue damage and organ failure It is a valuable biomarker for assessing infection severity and therapeutic outcomes in sepsis and inflammatory conditions

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