Pig Interferon Beta (IFNb) Protein

Este producto es parte de IFNB1 - interferon beta 1
Pig Interferon Beta (IFNb) Protein

Pida mas información

935106861

info@markelab.com

Precio

455€ (50 µg)

Protein IFNB1

proveedor

Abbexa

reference

abx067346

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Interferon Beta (IFNb) is a recombinant Pig protein produced in a Prokaryotic expression system (E. coli).


Background

Interferon Beta 1 (IFNB1) is a type I interferon with a critical role in antiviral defense and immunoregulation. Produced predominantly by fibroblasts, epithelial cells, and macrophages, IFNB1 is rapidly secreted in response to viral infections and pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors, such as Toll-like receptors (TLRs). Upon secretion, IFNB1 binds to the interferon alpha/beta receptor (IFNAR), triggering the JAK-STAT signaling pathway. This leads to the transcription of interferon-stimulated genes (ISGs), which orchestrate antiviral responses, including the inhibition of viral replication, degradation of viral RNA, and promotion of apoptosis in infected cells. IFNB1 also enhances antigen presentation by upregulating major histocompatibility complex (MHC) class I molecules and bolsters the activation and proliferation of natural killer (NK) cells and cytotoxic T lymphocytes. Clinically, recombinant forms of IFNB1 are widely used in the treatment of multiple sclerosis (MS), where they modulate the inflammatory response and reduce disease progression. Its role in other autoimmune and infectious diseases continues to be an area of active research.

Características del producto

category

Proteins and Peptides


origin

Pig


host

E. coli


immunogen target

Interferon Beta (IFNb)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 49.6 kDa Observed MW (SDS-PAGE): 50 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met22-Asn186 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IFNB1


dry ice

No


availability

Shipped within 5-7 working days.


alias

IFB,IFF,IFNB,IFN-beta,IFN-beta 1,Fibroblast interferon 1,IFNB1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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