Dog Interferon Beta (IFNb) Protein

Pida mas información
935106861
info@markelab.com
Precio
468€ (50 µg)
Protein IFNB1
proveedor
Abbexareference
abx067342Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Dog Interferon Beta (IFNb) is a recombinant Dog protein produced in a Prokaryotic expression system (E. coli).
Background
Interferon Beta 1 (IFNB1) is a type I interferon with a critical role in antiviral defense and immunoregulation. Produced predominantly by fibroblasts, epithelial cells, and macrophages, IFNB1 is rapidly secreted in response to viral infections and pathogen-associated molecular patterns (PAMPs) recognized by pattern recognition receptors, such as Toll-like receptors (TLRs). Upon secretion, IFNB1 binds to the interferon alpha/beta receptor (IFNAR), triggering the JAK-STAT signaling pathway. This leads to the transcription of interferon-stimulated genes (ISGs), which orchestrate antiviral responses, including the inhibition of viral replication, degradation of viral RNA, and promotion of apoptosis in infected cells. IFNB1 also enhances antigen presentation by upregulating major histocompatibility complex (MHC) class I molecules and bolsters the activation and proliferation of natural killer (NK) cells and cytotoxic T lymphocytes. Clinically, recombinant forms of IFNB1 are widely used in the treatment of multiple sclerosis (MS), where they modulate the inflammatory response and reduce disease progression. Its role in other autoimmune and infectious diseases continues to be an area of active research.
Características del producto
category
Proteins and Peptides
origin
Dog
host
E. coli
immunogen target
Interferon Beta (IFNb)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
50 µg
size 2
100 µg
size 3
200 µg
size 4
500 µg
size 5
1 mg
observerd MW
Molecular Weight: Calculated MW: 50.1 kDa Observed MW (SDS-PAGE): 47 kDa Concentration: Prior to lyophilization: 150 µg/ml Sequence Fragment: Ala21-Asn186 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IFNB1
dry ice
No
availability
Shipped within 5-7 working days.
alias
IFB,IFF,IFNB,IFN-beta,IFN-beta 1,Fibroblast interferon 1,IFNB1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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