Pig Cluster of Differentiation 40 Ligand / TNFSF5 (CD40LG) Protein
481€ (50 µg)
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name
Pig Cluster of Differentiation 40 Ligand / TNFSF5 (CD40LG) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065938
tested applications
WB, SDS-PAGE
Description
Recombinant Cluster Of Differentiation 40 Ligand (CD40L) is a recombinant Pig protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cluster of Differentiation 40 Ligand / TNFSF5 (CD40LG) |
| Host | E. coli |
| Origin | Pig |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 43.3 kDa Observed MW (SDS-PAGE): 44 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe111-Leu261 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 500 µg |
| Size 5 | 1 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q95MQ5 |
| Alias | T-cell antigen Gp39,IGM,IMD3,TRAP,gp39,CD154,CD40L,HIGM1,T-BAM,TNFSF5,hCD40L,TNF-related activation protein,Tumor necrosis factor ligand superfamily member 5 |
| Background | Protein CD40LG |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD40 ligand (CD40LG), also known as CD154 or TNFSF5, is a transmembrane protein expressed primarily on the surface of activated T cells and, to a lesser extent, on platelets and other cell types. It is a key member of the tumor necrosis factor (TNF) superfamily and functions as a ligand for CD40, a receptor found on the surface of various immune cells, including B cells, dendritic cells, macrophages, and endothelial cells. CD40LG-CD40 interactions are essential for effective immune responses, promoting T-cell-B-cell cooperation, antigen presentation, and the production of antibodies. Mutations in CD40LG are linked to X-linked hyper-IgM syndrome (XHIM), a primary immunodeficiency disorder, highlighting the protein's importance in immune system regulation. The CD40LG-CD40 axis also plays a role in the development of autoimmune diseases, cardiovascular disorders, and cancer, where the interaction is implicated in chronic inflammation and pathological immune activation.
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