Human Procollagen Type I C-Terminal Propeptide (PICP) Peptide (OVA)
494€ (100 µg)
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Name
Human Procollagen Type I C-Terminal Propeptide (PICP) Peptide (OVA)
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx165593
Tested Applications
WB, SDS-PAGE
Description
Procollagen I C-Terminal Proprotein Protein is a Human protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Procollagen Type I C-Terminal Propeptide (PICP) |
| Host | Synthetic |
| Assay Type | Activity: Not tested Sequence Fragment: Ser1193-Tyr1216 |
| Origin | Human |
| Conjugation | OVA |
| Expression | Synthetic |
| Purity | > 90% |
| Size 1 | 100 µg |
| Size 2 | 200 µg |
| Size 3 | 500 µg |
| Size 4 | 1 mg |
| Size 5 | 5 mg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 10 mM PBS, pH 7.4. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | C-Propeptide Of Type I Procollagen,Procollagen I Carboxy Terminal Propeptide, P1CP |
| Background | Protein PICP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 2.5 mg/ml |
Background
Procollagen Type I C-Terminal Propeptide (PICP) is a cleavage product of type I procollagen, the precursor of type I collagen, which is the most abundant structural protein in the extracellular matrix of connective tissues. PICP is released into the bloodstream during the synthesis of type I collagen, making it a reliable biomarker for collagen synthesis and turnover. It is widely used in clinical and research settings to assess bone formation, as increased levels of PICP correlate with osteoblast activity and are indicative of bone remodeling or conditions such as osteoporosis and metabolic bone diseases. Elevated PICP levels can also occur in fibrotic conditions, including liver fibrosis, cardiac fibrosis, and certain cancers, reflecting excessive collagen deposition in affected tissues. Measurement of PICP is typically performed using immunoassays, and its levels can provide insight into the effectiveness of therapeutic interventions aimed at modulating collagen synthesis or tissue remodeling. Additionally, PICP is a key player in the assembly and stabilization of collagen fibrils, facilitating proper extracellular matrix organization. Dysregulation of PICP processing or collagen deposition can lead to pathological states, highlighting its importance in connective tissue health and disease.
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